The molecular identity of the TLQP-21 peptide receptor
| Autor: | Bhavani S. Sahu, Stephen R.J. Salton, Megin E. Nguyen, Yuk Y. Sham, Vinayak Ghosh, Pedro Rodriguez, Maria Razzoli, Jean Pierre Pallais, Alessandro Bartolomucci |
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| Rok vydání: | 2021 |
| Předmět: |
Receptors
Peptide G-protein-coupled receptor Complement Neuropeptide Review Biology C3a Receptors G-Protein-Coupled Mitochondrial Proteins Cellular and Molecular Neuroscience Mice gC1QR medicine Adipocytes Animals Humans HSPA8 Amino Acid Sequence Receptor Molecular Biology G protein-coupled receptor Pharmacology TLQP-21 Neurodegeneration HSC70 Heat-Shock Proteins VGF Biological activity Cell Biology medicine.disease Peptide Fragments Receptors Complement C3aR1 Mechanism of action Molecular Medicine Microglia Signal transduction medicine.symptom Carrier Proteins Neuroscience Signal Transduction |
| Zdroj: | Cellular and Molecular Life Sciences |
| ISSN: | 1420-9071 |
| Popis: | The TLQP-21 neuropeptide has been implicated in functions as diverse as lipolysis, neurodegeneration and metabolism, thus suggesting an important role in several human diseases. Three binding targets have been proposed for TLQP-21: C3aR1, gC1qR and HSPA8. The aim of this review is to critically evaluate the molecular identity of the TLQP-21 receptor and the proposed multi-receptor mechanism of action. Several studies confirm a critical role for C3aR1 in TLQP-21 biological activity and a largely conserved mode of binding, receptor activation and signaling with C3a, its first-identified endogenous ligand. Conversely, data supporting a role of gC1qR and HSPA8 in TLQP-21 activity remain limited, with no signal transduction pathways being described. Overall, C3aR1 is the only receptor for which a necessary and sufficient role in TLQP-21 activity has been confirmed thus far. This conclusion calls into question the validity of a multi-receptor mechanism of action for TLQP-21 and should inform future studies. |
| Databáze: | OpenAIRE |
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