DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
| Autor: | Wellington Sun, Michael A. Eller, Kovit Pattanapanyasat, S Sarasombath, Angela Granelli-Piperno, Jennifer S. Finke, Timothy Burgess, Deborah L. Birx, Boonrat Tassaneetrithep, Ralph M. Steinman, Sarah J. Schlesinger, Mary A. Marovich, Christine Trumpfheller |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
receptor
Immunology Antigen presentation Receptors Cell Surface Dengue virus medicine.disease_cause Article virus receptor Dengue fever Dengue 03 medical and health sciences flavivirus medicine Immunology and Allergy antigen-presenting cells Humans Antibody-dependent enhancement Lectins C-Type Serotyping Antigen-presenting cell Cells Cultured 030304 developmental biology 0303 health sciences biology 030306 microbiology Virus receptor Antibodies Monoclonal Dendritic Cells Dengue Virus medicine.disease biology.organism_classification Flow Cytometry Virology 3. Good health DC-SIGN Flavivirus biology.protein lectin Receptors Virus Cell Adhesion Molecules |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection. |
| Databáze: | OpenAIRE |
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