A Review of Infants With Localized Neuroblastoma That Evolve to Stage 4s Disease
| Autor: | Bruno De Bernardi, Katia Mazzocco, Stefania Sorrentino, Elvira Pota, Massimo Provenzi, Angela Rita Sementa, Anna Rita Gigliotti, Anna Maria Caroleo, Claudio Granata, Monica Muraca, Stefano Avanzini |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Disease Systemic therapy Lesion Neuroblastoma Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Stage (cooking) Young adult Child Localized neuroblastoma Neoplasm Staging business.industry Infant Newborn Clinical course Infant Adrenalectomy Hematology medicine.disease Oncology Child Preschool 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Female medicine.symptom business Follow-Up Studies 030215 immunology |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 42:e483-e487 |
| ISSN: | 1077-4114 |
| Popis: | The authors describe a newborn diagnosed with localized neuroblastoma that evolved to stage 4s at the age of 5 months. Peculiar features of the case included a bilateral adrenal primary, the skin as the only metastatic site, and the development of a muscular lesion late in the clinical course. The patient underwent left adrenalectomy and all other lesions regressed without further therapy. The case prompted a search for similar cases both in the Italian Neuroblastoma Registry and in the literature. All patients identified, although variously treated, survived with the exception of the 2 with MYCN gene amplification. We conclude that infants with neuroblastoma who undergo a transition from a localized to stage 4s disease could be less rare than expected. In the absence of unfavorable biology, a wait-and-see policy with strict follow-up could be adopted for these patients, avoiding potentially damaging systemic therapy. |
| Databáze: | OpenAIRE |
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