Aerobic cervical bacteriology and antibiotic sensitivity patterns in patients with advanced cervical cancer before and after radiotherapy at a national referral hospital in Uganda
| Autor: | Fatuma Namusoke, Louis Mubangizi, Twaha Mutyaba |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Antibiotic sensitivity medicine.medical_treatment Antibiotics Uterine Cervical Neoplasms Cervix Uteri Microbial Sensitivity Tests Gastroenterology Reproductive Tract Infections Chocolate agar chemistry.chemical_compound Internal medicine medicine Humans Uganda External beam radiotherapy Prospective Studies Cervix Secondary Care Centers Aged Cervical cancer Aged 80 and over business.industry Microbiota Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Surgery Bacteria Aerobic medicine.anatomical_structure chemistry Gentamicin Female business MacConkey agar medicine.drug |
| Zdroj: | International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 126(1) |
| ISSN: | 1879-3479 |
| Popis: | Objective To determine prevalent aerobic cervical bacteria and sensitivity to commonly used antibiotics in patients with advanced cervical cancer before and after 4 weeks of external beam radiotherapy (EBRT). Methods Cervical swabs were collected prior to the initial radiation dose and after 4 weeks of radiotherapy at Mulago Hospital. Aerobic culture was performed on blood agar, chocolate agar, and MacConkey agar, and incubated at 35–37 ° for 24–48 hours. Isolates were identified using colonial morphology, Gram staining, and biochemical analysis. Sensitivity testing was performed via Kirby–Bauer disk diffusion and dilution. Differences in the proportions of bacteria isolated before and after radiotherapy were compared. Paired t test was used to obtain differences in sensitivity before and after radiotherapy. Results Normal flora increased significantly after EBRT (P = 0.02). There was no significant change in overall proportion of positive cultures. Sensitivity to commonly used antibiotics improved (P = 0.05) and resistance significantly decreased (P = 0.005). Significant differences were seen mainly with ciprofloxacin, ceftriaxone, and gentamicin. Conclusion Four weeks of EBRT did not sterilize the cervix but resulted in an increase in normal flora. Radiotherapy appeared to reduce resistance to commonly used antibiotics. Sensitivity to chloramphenicol was higher than for the more commonly used antibiotics. |
| Databáze: | OpenAIRE |
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