Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience
| Autor: | Ian Y. H. Wong, Alex L K Ng, Kelvin K. W. To, Chile Chi-Lai Choi, Keith Shun-Kit Chan, Leonard Hsu Yuen, Suk-Ming Yim, Jimmy Shiu-Ming Lai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Visual acuity Article Subject Pseudomonas aeruginosa medicine.drug_class business.industry Antibiotics Ophthalmology and optometry medicine.disease_cause Logistic regression medicine.disease Medical sciences Surgery Keratitis Contact lens Ophthalmology lcsh:Ophthalmology lcsh:RE1-994 Internal medicine medicine Risk factor medicine.symptom business Staphylococcus Research Article |
| Zdroj: | Journal of Ophthalmology, Vol 2015 (2015) Journal of Ophthalmology |
| ISSN: | 2090-0058 |
| Popis: | PURPOSE: To study the risk factors, microbial profile, antibiotic susceptibility pattern, and outcome for microbial keratitis over the past 10 years in a tertiary center in Hong Kong. METHODS: All cases with corneal scraping performed in Queen Mary Hospital, Hong Kong from January 2004 to December 2013 were included. Clinical outcome was defined as poor if the final visual acuity (VA) was abnormal or worse than presenting VA, a major complication occurred, or therapeutic keratoplasty was required. RESULTS: 347 scrapes were performed in the 10-year period growing 130 microorganisms (32.3% culture positive rate). Contact lens use was the commonest risk factor. The commonest isolates were coagulase-negative Staphylococcus and Pseudomonas aeruginosa. Fluoroquinolone susceptibility was tested in 47 Gram-negative bacteria with 93.6% susceptibility (100% for Pseudomonas). 90.7% of cases had good visual outcome.Multivariate logistic regression showed age (𝑝 = 0.03), trauma (𝑝 = 0.006), and ulcer size >3mm (𝑝 = 0.039) to be independently associated with poor outcome. CONCLUSION: There was no shifting trend in the isolate distribution or emergence of resistant strains in our study. Contact lens wear was the commonest risk factor, with Pseudomonas being the most frequent isolate in this group. It remained 100% susceptible to fluoroquinolones and 97% cases had good visual outcome. © Hindawi Publishing Corporation. published_or_final_version |
| Databáze: | OpenAIRE |
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