An overview on dosage forms and formulation strategies for vaccines and antibodies oral delivery
| Autor: | Virginie Busignies, Faten Madani, Pierre Tchoreloff, Hassana Hsein |
|---|---|
| Přispěvatelé: | Institut de Mécanique et d'Ingénierie (I2M), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Université de Bordeaux, IPB ENSCBP, CNRS UMR 5295, Institut I2M, Pessac, France, Transferts, écoulements, fluides, énergétique (TREFLE), Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Computer science
Chemistry Pharmaceutical Pharmaceutical Science Administration Oral formulation 02 engineering and technology 030226 pharmacology & pharmacy Dosage form Antibodies 03 medical and health sciences [SPI]Engineering Sciences [physics] 0302 clinical medicine Drug Delivery Systems Oral route Animals Humans Biomolecules Dosage Forms Vaccines oral administration General Medicine 021001 nanoscience & nanotechnology 3. Good health delivery systems Biochemical engineering Nanocarriers 0210 nano-technology |
| Zdroj: | Pharmaceutical Development and Technology Pharmaceutical Development and Technology, Taylor & Francis, In press, 25 (2), pp.133-148. ⟨10.1080/10837450.2019.1689402⟩ |
| ISSN: | 1083-7450 1097-9867 |
| DOI: | 10.1080/10837450.2019.1689402⟩ |
| Popis: | International audience; Most of biopharmaceuticals in clinical use today are available in a solution or suspension form and delivered by invasive routes (i.e. injection). However, several attempts have been made in order to develop effective oral formulations of ‘biomolecules’ characterized by a fragile structure and a low bioavailability. To achieve an efficient delivery of such molecules by non-parenteral route, in particular, via the oral route, novel concepts are needed not only to overcome significant enzymatic and diffusion barriers but also to ensure stability and biological activity. Vaccines and antibodies have a special interest as biomolecules because of their high therapeutic efficacy both in prevention and treatment of several chronic diseases. In this review, we would like to highlight the trends made in the development of pharmaceutical forms to deliver these molecules by the oral route. Hence, we will focus on the description of the different forms (solutions, suspensions, powders, tablets, micro and nanocarriers …) available today or under research study, in which product stability and efficacy are maintained. A special attention will be paid to the formulation strategies that may include the addition of several functional excipients and/or adjuvants, aiming to protect, to functionalize or to modulate their release in the body. |
| Databáze: | OpenAIRE |
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