Expressão de endotelina-1 e de óxido nítrico sintase endotelial em placentas normais e pré-eclâmpticas

Autor:	Aung Khaing, Aye Thet Swe, Cho Lwin Aung, Mya Mya Thwin, Mya Thanda Sein
Rok vydání:	2022
Předmět:	endothelial nitric oxide synthase placenta Endothelin-1 Nitric Oxide Synthase Type III Cesarean Section Placenta pré-eclâmpsia Obstetrics and Gynecology endotelina-1 preeclampsia Cross-Sectional Studies Pre-Eclampsia óxido nítrico sintase endotelial Pregnancy endothelin-1 Humans Female
Zdroj:	Revista Brasileira de Ginecologia e Obstetrícia, Volume: 44, Issue: 2, Pages: 125-132, Published: 08 APR 2022 Revista Brasileira de Ginecologia e Obstetrícia v.44 n.2 2022 Revista brasileira de ginecologia e obstetrícia Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) instacron:FEBRASGO
ISSN:	1806-9339
Popis:	Objective To investigate the expression of endothelin-1 (ET-1) and endothelial nitric oxide (NO) synthase (eNOS) in normal and preeclamptic (PE) placentae. Methods The present cross-sectional analytical study was performed in normal and PE primigravidae (n=10 in each group) who were admitted to the North Okkalapa General and Teaching Hospital from February 2019 to February 2020. Serum samples were collected immediately before delivery, and placental tissues were collected immediately after emergency or elective cesarean section. The expression of placental eNOS was measured by western blot, and the levels of ET-1 in placental tissue homogenates and in the serum were measured by enzyme-linked immunosorbent assay (ELISA). Results The PEgrouphadsignificantly higher serumlevelsof ET-1(median: 116.56 pg/mL; IQR: 89.14-159.62 pg/mL) than the normal group (median: 60.02 pg/mL; IQR: 50.89-94.37 pg/mL) (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2923318950d07f18cbdde0972d356f83 https://pubmed.ncbi.nlm.nih.gov/35213910 Zobrazit plný text záznamu