Immunocytochemical Localization of Transforming Growth Factor-α and Epidermal Growth Factor Receptor in Human Fallopian Tubes and Cumulus Cells
| Autor: | Lynn M. Westphal, Imam El-Danasouri, Ana Frances |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
endocrine system
medicine.medical_specialty TGF alpha Immunology Biology Embryonic and Fetal Development Pregnancy Epidermal growth factor Internal medicine medicine Humans Immunology and Allergy Epidermal growth factor receptor Autocrine signalling Fallopian Tubes Granulosa Cells urogenital system Obstetrics and Gynecology Transforming Growth Factor alpha Immunohistochemistry Cumulus oophorus Epithelium Cell biology ErbB Receptors medicine.anatomical_structure Endocrinology Reproductive Medicine Oocytes biology.protein Female Fallopian tube Transforming growth factor |
| Zdroj: | American Journal of Reproductive Immunology. 30:82-87 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.1993.tb00606.x |
| Popis: | PROBLEM: Transforming growth factor-a (TGF-α) has been shown to be a potent stimulant of oocyte maturation and embryonic development. The role of maternal growth factors and their mechanism of action in early mammalian development is not well understood. METHOD: In this study, the presence of TGF-α and epidermal growth factor receptor (EGF-R) in human cumulus cells and fallopian tubes was investigated by immunocytochemical techniques. RESULTS: The fallopian tube showed intense staining for TGF-α in the apical region of the epithelial cells, and the cumulus cells showed intense staining for EGF-R on cell membranes. CONCLUSION: The presence of TGF-α in the fallopian tube epithelium and its receptor on cumulus cells suggest a paracrine mechanism between maternal growth factors and the developing embryo. |
| Databáze: | OpenAIRE |
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