Endocrine effects of cannabis in male rats
| Autor: | G. Shipley, D. J. Brown, M. Novotny, M.P. Maskarinec, Robert B. Forney |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Metabolite medicine.medical_treatment Urine Pharmacology Androsterone Toxicology Steroid chemistry.chemical_compound Internal medicine mental disorders Male rats medicine Animals Dronabinol Testosterone Cannabis Androstenols biology Plant Extracts Estrogens biology.organism_classification Androstane-3 17-diol Hormones Rats Endocrinology chemistry Endocrine effects Gas chromatography |
| Zdroj: | Toxicology and Applied Pharmacology. 45:617-628 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(78)90123-0 |
| Popis: | Male Wistar rats were administered either synthetic Δ9-tetrahydrocannabinol (Δ9-THC) or Mexican cannabis extract at doses of 1, 5, 10, 25, and 50 mg of Δ9-THC/kg of body weight. Steroid concentrations in urine and blood were measured using glass capillary gas chromatography and individual metabolites were identified by gas chromatography/mass spectrometry. Plasma corticosterone and its metabolite were elevated in a dose-response fashion up to 25 mg/kg. While testosterone is unaltered by Δ9-THC, except at 50 mg/kg, ⊙ther metabolites with possible relation to androgen metabolism were elevated. Measurable amounts of estrogens were produced by male rats given the drugs. Additional alterations were seen in the concentrations of conjugated steroids. |
| Databáze: | OpenAIRE |
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