Efficacy and safety of rivaroxaban in patients with inferior vena cava filter placement without anticoagulation contraindications (EPICT): a prospective randomised controlled trial study protocol
| Autor: | Zhengdong Fang, Guangwei Yang, Zhenjie Liu, Wan Zhang, Li Yin, Zhenyu Shi, Linjun Wang, Jianing Yue, Libin Zhang, Yuefeng Zhu, Bin Gao, Miaomiao Li, Lubin Li, Xueying Ke, Zheng Gu, Wei Han |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Vena Cava Filters medicine.drug_class Inferior vena cava filter Cardiovascular Medicine vascular surgery Inferior vena cava Rivaroxaban medicine Humans Multicenter Studies as Topic Prospective Studies Randomized Controlled Trials as Topic clinical trials business.industry Contraindications Anticoagulant Warfarin Anticoagulants vascular medicine General Medicine thromboembolism medicine.disease Thrombosis Surgery Pulmonary embolism Clinical trial Treatment Outcome medicine.vein cardiovascular system Medicine Pulmonary Embolism business medicine.drug |
| Zdroj: | BMJ Open, Vol 11, Iss 10 (2021) BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | IntroductionInferior vena cava (IVC) filters are commonly used in patients with venous thromboembolism to prevent fatal pulmonary embolism, but the thrombosis risk increases after filter placement. Warfarin is a widely anticoagulant, but long-term monitoring and dose adjustments are required. Anticoagulation with rivaroxaban is more straightforward as it dose not require laboratory monitoring. This study compares the efficacy and safety of rivaroxaban and warfarin as an in anticoagulation therapy for patients with IVC filter placement.Methods and analysisThis is a multicentre, randomised controlled trial. In total, 200 patients with deep vein thrombosis (DVT) with IVC filter implantation from 10 hospitals will be recruited. The patients will be randomised to the experimental group (rivaroxaban) or the control group (nadroparin overlapped with warfarin). The primary outcomes include death of any cause, pulmonary embolism (PE)-related death, bleeding and recurrent PE/DVT. The secondary outcomes include the percentage of other vascular events, IVC filter retrieval failure and net clinical benefits. This study aims to provide reliable, verification for the efficacy and safety of rivaroxaban antithrombotic therapy after IVC filter placement.Ethics and disseminationThe study was approved by the Human Research Ethics Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine (approval number: (2019) 295). The results will be disseminated through presentations at scientific conferences and publications in peer-reviewed journalsTrial registration numberNCT04066764. |
| Databáze: | OpenAIRE |
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