Cancer phenotype as the outcome of an evolutionary game between normal and malignant cells

Autor: Fabio A. C. C. Chalub, S. Van Segbroeck, David Dingli, Jorge M. Pacheco, Francisco C. Santos
Přispěvatelé: DM - Departamento de Matemática, CMA - Centro de Matemática e Aplicações, Computational Modelling
Rok vydání: 2009
Předmět:
cancer ecology
Cancer Research
replicator
Disease
in-vivo
evolutionary
Multiple myeloma
Multiple Myeloma -- therapy
cancer dynamics
Genetics
Natural selection
of
dynamics
tumor-cells
Sciences bio-médicales et agricoles
Phenotype
inhibition
evolutionary game theory of cancer
multiple
myeloma
Oncology
somatic evolution of cancer
ecology
Multiple Myeloma
bone-disease
Multiple Myeloma -- pathology
Cancer dynamics
growth
inflammatory
Computational biology
system
Biology
Game Theory
SDG 3 - Good Health and Well-being
replicator cell dynamics
evolution
Genetic variation
medicine
Humans
cancer
Evolutionary Game Theory
Selection
Genetic
Letters to the Editor
theory
Molecular Diagnostics
somatic
Replicator cell dynamics
Cancer
staging
cell
medicine.disease
1-alpha
Transplantation
multiple-myeloma
osteoprotegerin
Somatic evolution of cancer
Cancer cell
Evolutionary game theory of cancer
game
Cancer ecology
protein
transplantation
Zdroj: British Journal of Cancer
British Journal of Cancer, 101 (7
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ISSN: 1532-1827
0007-0920
DOI: 10.1038/sj.bjc.6605288
Popis: There is variability in the cancer phenotype across individuals: two patients with the same tumour may experience different disease life histories, resulting from genetic variation within the tumour and from the interaction between tumour and host. Until now, phenotypic variability has precluded a clear-cut identification of the fundamental characteristics of a given tumour type.
Journal Article
Research Support, Non-U.S. Gov't
SCOPUS: ar.j
info:eu-repo/semantics/published
Databáze: OpenAIRE
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