| Autor: |
Celia Dominguez, Marieke Lamers, Samantha J. Hughes, Rebecca E. Jarvis, Grant Wishart, Helen L. Birch, Roland Bürli, Omar Aziz, Scott Pollack, Dawn Yates, Perla Breccia, Christopher A. Luckhurst, Philip Leonard, Andrew J. Stott, George McAllister, Kim L. Matthews, Elizabeth Anne Saville-Stones |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Popis: |
Potent and selective class IIa HDAC tetrasubstituted cyclopropane hydroxamic acid inhibitors were identified with high oral bioavailability that exhibited good brain and muscle exposure. Compound 14 displayed suitable properties for assessment of the impact of class IIa HDAC catalytic site inhibition in preclinical disease models. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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