Effects of a synbiotic formula on functional bowel disorders and gut microbiota profile during long-term home enteral nutrition (LTHEN): a pilot study
| Autor: | Federica Del Chierico, Paola Belci, Maria Carmine Scigliano, Filippo Fassio, Rosalba Galletti, Fabio Guagnini, Valentina D'Onofrio, Antonella De Francesco, Andrea Quagliariello, Lorenza Putignani, Pamela Vernocchi, Maria Vittoria Mancino, Maurizio Fadda, Roberta Morelli, Sofia Reddel, Giorgia Conta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Constipation Synbiotics Volatile Pilot Projects long-term home enteral nutrition (LTHEN) Gut flora Enteral administration Gastroenterology Irritable Bowel Syndrome Feces 0302 clinical medicine Surveys and Questionnaires Medicine Nutrition and Dietetics biology bedridden patients Fatty Acids Biodiversity dysbiosis Methanobrevibacter Italy Biomarker (medicine) 030211 gastroenterology & hepatology Female medicine.symptom lcsh:Nutrition. Foods and food supply medicine.medical_specialty Formulated lcsh:TX341-641 Bedridden patients Diarrhoea Dysbiosis Gut microbiota Long-term home enteral nutrition (LTHEN) synbiotics Aged Fatty Acids Volatile Humans Prebiotics Probiotics Enteral Nutrition Food Formulated Gastrointestinal Microbiome Article 03 medical and health sciences Internal medicine synbiotics gut microbiota business.industry constipation biology.organism_classification medicine.disease diarrhoea 030104 developmental biology Parenteral nutrition Food long-term home enteral nutrition (LTHEN) synbiotics business Food Science |
| Zdroj: | Nutrients Volume 13 Issue 1 Nutrients, Vol 13, Iss 87, p 87 (2021) |
| Popis: | Long-term enteral nutrition (LTEN) can induce gut microbiota (GM) dysbiosis and gastrointestinalrelated symptoms, such as constipation or diarrhoea. To date, the treatment of constipationis based on the use of laxatives and prebiotics. Only recently have probiotics and synbiotics beenconsidered, the latter modulating the GM and regulating intestinal functions. This randomized open-label intervention study evaluated the effects of synbiotic treatment on the GM profile, itsfunctional activity and on intestinal functions in long-term home EN (LTHEN) patients. TwentyLTHEN patients were recruited to take enteral formula plus one sachet/day of synbiotic (interventiongroup, IG) or enteral formula (control group, CG) for four months and evaluated for constipation, stool consistency, and GM and metabolite profiles. In IG patients, statistically significant reduction ofconstipation and increase of stool consistency were observed after four months (T1), compared toCG subjects. GM ecology analyses revealed a decrease in the microbial diversity of both IC and CGgroups. Biodiversity increased at T1 for 5/11 IG patients and Methanobrevibacter was identified asthe biomarker correlated to the richness increase. Moreover, the increase of short chain fatty acidsand the reduction of harmful molecules have been correlated to synbiotic administration. Synbioticsimprove constipation symptoms and influences Methanobrevibacter growth in LTHEN patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|