Neonatal Thyroid-Stimulating Hormone Screening as a Monitoring Tool for Iodine Deficiency in Turkey
| Autor: | Deniz Acıcan, Başak Tezel, Bekir Keskinkılıç, Nuran Sahin, Sema Ozbas, Nilgün Çaylan, Şirin Aydın |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Turkey Endocrinology Diabetes and Metabolism Prevalence Thyroid-stimulating hormone Thyrotropin chemistry.chemical_element 030209 endocrinology & metabolism Iodine screening program World health 03 medical and health sciences Neonatal Screening 0302 clinical medicine Endocrinology newborn medicine Humans Gynecology Newborn screening Obstetrics business.industry Infant Newborn medicine.disease Thyroid Diseases Iodine deficiency Congenital hypothyroidism chemistry Pediatrics Perinatology and Child Health Original Article Female business Monitoring tool 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5727 |
| DOI: | 10.4274/jcrpe.2526 |
| Popis: | Objective: Thyroid-stimulating hormone (TSH) level in neonates is recommended as an indicator for presence of iodine deficiency (ID) at a population level and as a monitoring tool in programs of iodine supplementation. The purpose of this study, based on data from the National Newborn Screening Program (NNSP) for congenital hypothyroidism (CH) in 2014, was to analyze neonatal TSH levels to predict the current status of iodine nutrition in Turkey. Methods: According to screening methodology, heel-prick blood samples of newborns were collected on filter paper cards usually on day 3-5 after birth (or shortly before discharge). Results of samples collected >48 h after birth were analyzed. The degree of severity of ID was assessed by using the epidemiologic criteria of the World Health Organization (WHO). Elevated TSH levels (>5 mIU/L) were processed and classified according to province, region, birth season, and sampling time. Results: A total of 1,298531 newborns were registered in the NNSP for the CH database. Of those, 1,270311 newborns had screening results collected >48 h after birth and were included in the statistical analyses. The national prevalence of elevated TSH was 7.2%. While the Gaziantep sub-region had the highest TSH elevation rate (15.9%), the Tekirdağ sub-region had the lowest rate (4.0%; p |
| Databáze: | OpenAIRE |
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