Detection of phase I IgG antibodies to Coxiella burnetii with EIA as a screening test for blood donations
| Autor: | Peter M. Schneeberger, H. L. Zaaijer, Cornelia C. H. Wielders, B. Schimmer, M. C. A. Wegdam-Blans, Jamie C. E. Meekelenkamp, W. van der Hoek |
|---|---|
| Přispěvatelé: | Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Microbiology (medical) Blood transfusion Adolescent medicine.medical_treatment Blood Donors Q fever Immunofluorescence Sensitivity and Specificity Immunoenzyme Techniques Young Adult medicine Humans Mass Screening Child Aged Netherlands Aged 80 and over biology medicine.diagnostic_test Outbreak General Medicine Middle Aged Coxiella burnetii biology.organism_classification medicine.disease bacterial infections and mycoses Antibodies Bacterial Virology Titer Infectious Diseases Immunoglobulin G Immunoassay Immunology biology.protein Female Antibody Q Fever |
| Zdroj: | European journal of clinical microbiology & infectious diseases, 31(11), 3207-3209. Springer Verlag |
| ISSN: | 0934-9723 |
| Popis: | The presence of a high phase I IgG antibody titre may indicate chronic infection and a risk for the transmission of Coxiella burnetii through blood transfusion. The outbreak of Q fever in the Netherlands allowed for the comparison of an enzyme immunoassay (EIA) with the reference immunofluorescence assay (IFA) in a large group of individuals one year after acute Q fever. EIA is 100 % sensitive in detecting high (a parts per thousand yen1:1,024) phase I IgG antibody titres. The cost of screening with EIA and confirming all EIA-positive results with IFA is much lower than screening all donations with IFA. This should be taken into account in cost-effectiveness analyses of screening programmes |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink