Directed Zincation with TMPZnCl·LiCl and Further Functionalization of the Tropolone Scaffold
| Autor: | Diana Haas, Sophia Schwarz, Daniela Sustac-Roman, Paul Knochel |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Scaffold
010405 organic chemistry Negishi coupling Chemistry Organic Chemistry Halogenation 010402 general chemistry 01 natural sciences Biochemistry Tropolone 0104 chemical sciences Acylation chemistry.chemical_compound Reagent Organic chemistry Surface modification Physical and Theoretical Chemistry |
| Zdroj: | Organic letters. 18(24) |
| ISSN: | 1523-7052 |
| Popis: | The directed zincation of tropolone derivatives was achieved using TMPZnCl·LiCl. Various functionalizations of the zincated intermediates by halogenation, acylation, allylation, and Negishi cross-coupling were successfully performed. Additionally, 1,8-conjugate addition–elimination reactions with a variety of arylmagnesium and secondary alkylzinc reagents were carried out to further elaborate the tropolone core. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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