Serum micro-RNA Identifies Early Stage Colorectal Cancer in a Multi-Ethnic Population
| Autor: | Michio Machida, David S. Shaeffer, Jessica R Shiosaki, Maarit Tiirikainen, Scott K. Kuwada, Peter Bryant-Greenwood, Kuniaki Kojima, Kazuhiro Sakamoto, Junji Machi, Makoto Takahashi, Karolina Peplowska |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty diagnosis Colorectal cancer Population Ethnic group Hawaii 03 medical and health sciences 0302 clinical medicine Japan Internal medicine multi-ethnic microRNA Biomarkers Tumor Ethnicity medicine Humans Stage (cooking) education Aged education.field_of_study business.industry micro-RNA General Medicine Middle Aged Prognosis medicine.disease Colon cancer screening digestive system diseases Multiethnic population Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Homogeneous Case-Control Studies 030220 oncology & carcinogenesis Female Colorectal Neoplasms business Research Article Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| Popis: | Objective Certain microRNAs (miR) have been previously described to be dysregulated in cancers and can be detected in blood samples. Studies examining the utility of miRs for colon cancer screening have primarily been performed in ethnically homogeneous groups of patients, thus the performance of miRs in multiethnic populations is unknown. Methods Four miRs were selected that were shown to be aberrantly expressed in the blood or stool of patients with colorectal cancer (CRC) of various ethnicities. In this study, the ability of these miRs to discern early stage CRC was determined in a previously untested multiethnic population of 73 CRC cases and 18 controls. Results The ratios of non-vesicular to extracellular vesicular levels of miR's -21, -29a, and -92a were statistically and quantitatively related to CRC stage compared to controls. Conclusion Serum levels of miR-21, miR-29a and miR-92a were able to significantly detect early stage CRC in a multiethnic and previously untested population. . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|