Fundamental insights in early-stage inclusion body formation

Autor:	Julian Kopp, Benjamin Bayer, Christoph Slouka, Gerald Striedner, Mark Dürkop, Oliver Spadiut
Rok vydání:	2022
Předmět:	Bioengineering Applied Microbiology and Biotechnology Biochemistry Biotechnology
Zdroj:	Microbial biotechnologyREFERENCES.
ISSN:	1751-7915
Popis:	Early-stage inclusion body formation is still mysterious. Literature is ambiguous about the existence of rod-shaped protein aggregates, a potential sponge-like inclusion body scaffold as well as the number of inclusion bodies per Escherichia coli cell. In this study, we verified the existence of rod-shaped inclusion bodies, confirmed their porous morphology, the presence of multiple protein aggregates per cell and modelled inclusion body formation as function of the number of generations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290e3d911fc03302493951e1064a6d52 https://pubmed.ncbi.nlm.nih.gov/35830603 Zobrazit plný text záznamu Plný text