Pulse dexamethasone therapy versus pulse methylprednisolone therapy for treatment of Graves′s ophthalmopathy
| Autor: | Rajiv Tyagi, Manish Gutch, KK Gupta, Sanjay Saran, Pushpaltha Agroyia, Rajeev Philip |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Exophthalmos Endocrinology Diabetes and Metabolism Brief Communication lcsh:Diseases of the endocrine glands. Clinical endocrinology law.invention Graves′ ophthalmopathy Graves' ophthalmopathy Endocrinology Fulminant hepatic failure Randomized controlled trial law Graves’ ophthalmopathy medicine pulse methylprednisolone therapy lcsh:RC799-869 pulse dexamethasone therapy Dexamethasone lcsh:RC648-665 Pulse (signal processing) business.industry medicine.disease Surgery Methylprednisolone lcsh:Diseases of the digestive system. Gastroenterology medicine.symptom business Complication medicine.drug |
| Zdroj: | Indian Journal of Endocrinology and Metabolism, Vol 17, Iss 7, Pp 157-159 (2013) Indian Journal of Endocrinology and Metabolism |
| ISSN: | 2230-9500 2230-8210 |
| Popis: | Pulse methylprednisolone therapy is the recommended therapy for moderate to severe and active ophthalmopathy, but high dose pulse methylprednisolone therapy is marred by the chances of fulminant hepatic failure and the high cost of therapy. Dexamethasone pulse therapy can be considered as an alternative to pulse methylprednisolone therapy. A prospective randomized control trial was carried out in 21 patients comparing pulse dexamethasone therapy versus pulse methyprednisolone therapy in Graves's ophthalmopathy. This study proved that pulse dexamethasone therapy is a cheaper and equally effective therapy for Graves's ophthalmopathy and the cost of therapy is reduced to at least 1/8(th) s. Furthermore, dexa had a better effect on reduction of exophthalmos. The dreaded complication of fulminant hepatic failure, associated with high dose of methylprednisolone, is not seen with dexa therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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