Recent advances in modeling sleep: from the clinic to society and disease
| Autor: | Kimaya Lecamwasam, John H. Abel, Elizabeth B. Klerman, Melissa A. St. Hilaire |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Role modeling Cognition Disease Neurophysiology Precision medicine Sleep medicine Sleep in non-human animals Article 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Physiology (medical) medicine Psychology 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Curr Opin Physiol |
| ISSN: | 2468-8673 |
| DOI: | 10.1016/j.cophys.2019.12.001 |
| Popis: | In the past few decades, advances in understanding sleep-wake neurophysiology have occurred hand-in-hand with advances in mathematical modeling of sleep and wake. In this review, we summarize recent updates in modeling the timing and durations of sleep and wake, the underlying neurophysiology of sleep and wake, and the application of these models in understanding cognition and disease. Throughout, we highlight the role modeling has played in developing our understanding of sleep and its underlying mechanisms. We present open questions and controversies in the field and propose the utility of individualized models of sleep for precision sleep medicine. |
| Databáze: | OpenAIRE |
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