The role of the FTD-ALS associated C9orf72 expansion in suicide victims

Autor:	Terttu Särkioja, Helinä Hakko, Eino Solje, Mikko Hiltunen, Anne M. Remes, Pirkko Riipinen, Marjo Laitinen, Seppo Helisalmi
Rok vydání:	2016
Předmět:	Adult Male medicine.medical_specialty Adolescent Poison control Disease Suicide prevention Young Adult 03 medical and health sciences 0302 clinical medicine C9orf72 medicine Humans Amyotrophic lateral sclerosis Psychiatry Finland Aged Retrospective Studies Aged 80 and over DNA Repeat Expansion C9orf72 Protein 030214 geriatrics Amyotrophic Lateral Sclerosis Proteins Middle Aged medicine.disease Suicide Neurology Frontotemporal Dementia Cohort Female Neurology (clinical) Trinucleotide repeat expansion Psychology 030217 neurology & neurosurgery Frontotemporal dementia
Zdroj:	Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 17:589-592
ISSN:	2167-9223 2167-8421
DOI:	10.1080/21678421.2016.1203337
Popis:	Impulsive and aggressive traits are not only common features displayed by patients with behavioural variant frontotemporal dementia (bvFTD), they may well be the first clinical manifestations of the disease. In addition, suicidal behaviour has been postulated to be a symptom of bvFTD. A hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) is the major genetic cause for familial bvFTD. During recent years, several genetic factors predisposing to suicide have been identified, but there are no previous studies analysing the role of the C9orf72 expansion in suicides. In the present study, we aimed to analyse the prevalence of the C9orf72 expansion in unselected suicide victims. The prevalence of the C9orf72 expansion was analysed in a cohort of 109 Finnish victims of suicide (mean age at death 46.1 years; range 18-86 years). The C9orf72 expansion was analysed from the post mortem blood samples. Results showed that no abnormal length C9orf72 expansions were detected in the study cohort. In conclusion, even though suicidal behaviour may be encountered in bvFTD patients, the C9orf72 expansion is not a common genetic finding in unselected suicide victims.
Databáze:	OpenAIRE
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