l -Ornithine stimulates growth hormone release in a manner dependent on the ghrelin system
| Autor: | Mamoru Tanida, Junya Nakato, Ryuhei Kanamoto, Saori Akiduki, Takafumi Mizushige, Kousaku Ohinata, Yee Yin Ho |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Ornithine 0301 basic medicine medicine.medical_specialty Duodenum Hypothalamus 030209 endocrinology & metabolism Propranolol 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Secretion Rats Wistar Receptors Ghrelin Receptor Chemistry Stomach fungi digestive oral and skin physiology Antagonist General Medicine respiratory system Ghrelin Growth hormone secretion Rats 030104 developmental biology Endocrinology medicine.anatomical_structure Growth Hormone sense organs hormones hormone substitutes and hormone antagonists Food Science medicine.drug |
| Zdroj: | Food & Function. 8:2110-2114 |
| ISSN: | 2042-650X 2042-6496 |
| Popis: | We found that intraduodenal administration of l-ornithine (l-Orn) stimulates growth hormone (GH) secretion in Wistar rats, and then investigated its mechanism. GH-releasing activity after intraduodenal administration of l-Orn was blocked by [d-Lys3]-GHRP-6, an antagonist of the ghrelin receptor; however, l-Orn (100 μM) has no affinity for the ghrelin receptor, suggesting that the GH-releasing activity of l-Orn is mediated via ghrelin release and activation of the ghrelin receptor. Intraduodenally administered l-Orn increased ghrelin mRNA expression in the duodenum but not in the stomach or hypothalamus. In addition, l-Orn-induced GH-releasing activity was inhibited by propranolol, an antagonist of β-adrenergic receptor, which is known to be coupled to ghrelin release. In conclusion, intraduodenally administered l-Orn stimulates GH secretion through the sympathetic nervous and ghrelin systems. |
| Databáze: | OpenAIRE |
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