Serially Ordered Magnetization of Nanoclusters via Control of Various Transition Metal Dopants for the Multifractionation of Cells in Microfluidic Magnetophoresis Devices
| Autor: | Seungmin Han, Bongsoo Kim, Seo Ryung Bae, Moo Kwang Shin, Seungjoo Haam, Il Moon, Yong Min Huh, Bumjoon Cha, Hye Yeong Son, Eunji Jang, Unyong Jeong, Hyun Ouk Kim, Byunghoon Kang |
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| Rok vydání: | 2016 |
| Předmět: |
Surface Properties
Microfluidics Analytical chemistry Cell Separation 02 engineering and technology 01 natural sciences Analytical Chemistry Nanoclusters Magnetization Cell Line Tumor Atom Transition Elements Physics::Atomic and Molecular Clusters Humans Particle Size Magnetite Nanoparticles Dopant Chemistry Magnetic Phenomena 010401 analytical chemistry Doping Microfluidic Analytical Techniques 021001 nanoscience & nanotechnology 0104 chemical sciences Magnetic field Chemical physics 0210 nano-technology |
| Zdroj: | Analytical Chemistry. 88:1078-1082 |
| ISSN: | 1520-6882 0003-2700 |
| Popis: | A novel method (i.e., continuous magnetic cell separation in a microfluidic channel) is demonstrated to be capable of inducing multifractionation of mixed cell suspensions into multiple outlet fractions. Here, multicomponent cell separation is performed with three different distinguishable magnetic nanoclusters (MnFe2O4, Fe3O4, and CoFe2O4), which are tagged on A431 cells. Because of their mass magnetizations, which can be ideally altered by doping with magnetic atom compositions (Mn, Fe, and Co), the trajectories of cells with each magnetic nanocluster in a flow are shown to be distinct when dragged under the same external magnetic field; the rest of the magnetic characteristics of the nanoclusters are identically fixed. This proof of concept study, which utilizes the magnetization-controlled nanoclusters (NCs), suggests that precise and effective multifractionation is achievable with high-throughput and systematic accuracy for dynamic cell separation. |
| Databáze: | OpenAIRE |
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