PREDICTION OF TIME TRENDS IN RECOVERY OF COGNITIVE FUNCTION AFTER MILD HEAD INJURY
| Autor: | Toril Fagerheim, Tor Ingebrigtsen, Bertil Romner, Gry Wikran, Kay Müller, Tom Wilsgaard, Knut Waterloo |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Traumatic brain injury S100 Calcium Binding Protein beta Subunit Neuropsychological Tests Young Adult Apolipoproteins E Predictive Value of Tests Internal medicine medicine Craniocerebral Trauma Humans Glasgow Coma Scale Nerve Growth Factors Effects of sleep deprivation on cognitive performance Neuropsychological assessment Risk factor Prospective cohort study Aged Neurologic Examination medicine.diagnostic_test business.industry S100 Proteins Head injury Recovery of Function Middle Aged medicine.disease Magnetic Resonance Imaging Multivariate Analysis Linear Models Physical therapy Female Surgery Neurology (clinical) Cognition Disorders Tomography X-Ray Computed business Neurocognitive |
| Zdroj: | Neurosurgery. 64:698-704 |
| ISSN: | 0148-396X |
| Popis: | OBJECTIVE To investigate relations between predictors and outcomes, and especially to identify predictors influencing the time trend in recovery after mild traumatic brain injury. METHODS We included 59 patients with mild head injury in a prospective study. They underwent comprehensive assessment with neurological and neuroradiological examinations, serum S-100B analysis, and apolipoprotein E (APOE) genotyping. Neuropsychological testing was performed before and 6 months after discharge. Linear mixed models were used to assess associations between baseline predictors and neurocognitive performance and its change. RESULTS A Glasgow Coma Scale score of less than 15, traumatic brain injury demonstrated with computed tomography, magnetic resonance imaging, and serum S-100B greater than 0.14 microg/L predicted impaired cognitive performance both at baseline and after 6 months; APOE genotype did not. There was significant improvement of performance after 6 months. APOE-epsilon4 genotype was the only independent factor significantly predicting less improvement. CONCLUSION The presence of the APOE-epsilon4 allele predicts less recovery of cognitive function after mild head injury. |
| Databáze: | OpenAIRE |
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