Mechanisms mediating suppression of globin gene transcription in Danio rerio nonerythroid cells
| Autor: | Sergey V. Razin, Olga V. Iarovaia, Alexey A. Gavrilov, Natalia Klimenko, A. P. Kovina, N. V. Petrova, E. S. Ioudinkova |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Transcription Genetic Danio Locus (genetics) beta-Globins Biology Biochemistry 03 medical and health sciences alpha-Globins Transcription (biology) hemic and lymphatic diseases Animals Globin gene Gene Psychological repression Zebrafish 030102 biochemistry & molecular biology fungi General Medicine Zebrafish Proteins biology.organism_classification Cell biology 030104 developmental biology Histone Acetylation biology.protein |
| Zdroj: | Biochimie. 181 |
| ISSN: | 1638-6183 |
| Popis: | We studied the repression of adult and embryo-larval genes of the major globin gene locus in D. rerio fibroblasts. The results obtained suggest that at least some of the globin genes are repressed by Polycomb, similarly to human α-globin genes. Furthermore, within two α/β globin gene pairs, repression of α-type and β-type genes appears to be mediated by different mechanisms, as increasing the level of histone acetylation can activate transcription of only β-type genes. |
| Databáze: | OpenAIRE |
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