Rapidly increasing SARS-CoV-2 seroprevalence and limited clinical disease in three Malian communities: a prospective cohort study
| Autor: | Kaitlyn Sadtler, John Woodford, Mahamadoun H. Assadou, Jacquelyn Lane, Justin Doritchamou, Patrick E. Duffy, Jennifer Kwan, Irfan Zaidi, Alassane Dicko, Oumar Attaher, Mamady Kone, Issaka Sagara, Emily Higbee, M'Bouye Doucoure, Dominic Esposito, Amatigue Zeguime, Abdoulaye Katile |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
education.field_of_study
medicine.medical_specialty seroprevalence SARS-CoV-2 business.industry Population COVID-19 Mali Herd immunity AcademicSubjects/MED00290 West Africa Epidemiology Major Article Medicine Seroprevalence Cumulative incidence business Serostatus education Prospective cohort study Subclinical infection Demography |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| Popis: | Background The extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and transmission in Mali and the surrounding region is not well understood. We aimed to estimate the cumulative incidence of SARS-CoV-2 in 3 communities and understand factors associated with infection. Methods Between July 2020 and January 2021, we collected blood samples and demographic, social, medical, and self-reported symptoms information from residents aged 6 months and older over 2 study visits. SARS-CoV-2 antibodies were measured using a highly specific 2-antigen enzyme-linked immunosorbent assay optimized for use in Mali. We calculated cumulative adjusted seroprevalence for each community and evaluated factors associated with serostatus at each visit by univariate and multivariate analysis. Results Overall, 94.8% (2533/2672) of participants completed both study visits. A total of 31.3% (837/2672) were aged This study demonstrates a large, previously unquantified burden of SARS-COV-2 infection in the community in West Africa. In this young study population, there was limited evidence of severe illness and seropositivity rates that may approach hypothetical “herd immunity.” |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|