17Beta-estradiol promotes aggressive laryngeal cancer through membrane-associated estrogen receptor-alpha 36
| Autor: | Nofrat Schwartz, Zvi Schwartz, Reyhaan A. Chaudhri, Barbara D. Boyan, Agreen Hadadi |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Cancer Research Carcinogenesis Cell Survival Endocrinology Diabetes and Metabolism Antineoplastic Agents Apoptosis Biology medicine.disease_cause Article Metastasis chemistry.chemical_compound Endocrinology Downregulation and upregulation medicine Phospholipase D Humans Protein Isoforms Molecular Targeted Therapy Receptor Laryngeal Neoplasms Protein Kinase C Cell Proliferation Neoplasm Staging Estradiol Neovascularization Pathologic Endocrine and Autonomic Systems Carcinoma Estrogen Receptor alpha Cancer Membrane Proteins Laryngeal Neoplasm Middle Aged medicine.disease Vascular endothelial growth factor Oncology chemistry Drug Resistance Neoplasm Lymphatic Metastasis Cancer research Female Estrogen receptor alpha HeLa Cells |
| Zdroj: | Hormonescancer. 5(1) |
| ISSN: | 1868-8500 |
| Popis: | 17β-estradiol (E2) plays a key role in tumorigenesis by enhancing cell survivability and metastasis through its cytoplasmic receptors. Recently, a variant of estrogen receptor alpha, ERα36 has been implicated as a substantial mediator of E2’s proliferative and anti-apoptotic effects through rapid membrane-associated signaling, and cancers previously regarded as hormone-independent due to the absence of traditional receptors, may in fact be susceptible to E2. Despite rising from a secondary sex organ and having a clear gender disposition, laryngeal cancer is not uniformly accepted as hormone-dependent, even in the face of compelling evidence of E2 responsiveness. The aim of this study was to further elucidate the role of E2 in the tumorigenesis of laryngeal cancer, both in vitro and in vivo. ERα36 presence was evaluated in membranes of the laryngeal carcinoma cell line, Hep2, as well as in laryngeal tumor samples. In vitro, ERα36 was found to mediate rapid activation of protein kinase C and phospholipase D by E2, leading to increased proliferation and protection against chemotherapy-induced apoptosis. Furthermore, in response to E2 activation of ERα36, an upregulation of angiogenic and metastatic factors was observed. Clinical analysis of laryngeal tumors revealed a similar association between the amount of ERα36 and VEGF, and indicated a role in lymph node metastasis. These findings present compelling evidence of ERα36-dependent E2 signaling in laryngeal cancer. Thus, targeting ERα36 may reduce the deleterious effects of E2 in laryngeal cancer, ultimately suggesting the importance of anti-estrogen therapy or the production of novel drugs that specifically target ERα36. |
| Databáze: | OpenAIRE |
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