Analysis on therapeutic outcomes and prognostic factors of intracranial ependymoma: a report of 49 clinical cases in a single center
| Autor: | Chun Luo, Jiayi Yan, Wan Zhiping, Junle Zhu, Peiqin Chen, Jingliang Ye, Zhang Lei, Qian Jun, Feng Chen |
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| Rok vydání: | 2015 |
| Předmět: |
Ependymoma
Adult Male medicine.medical_specialty Prognostic variable Adolescent Dermatology Single Center Disease-Free Survival Young Adult medicine Humans Child Survival rate Retrospective Studies business.industry Brain Neoplasms Medical record Retrospective cohort study General Medicine Middle Aged medicine.disease Prognosis Combined Modality Therapy Surgery Hydrocephalus Survival Rate Psychiatry and Mental health Treatment Outcome Child Preschool Multivariate Analysis Female Neurology (clinical) Neurosurgery Neoplasm Recurrence Local business |
| Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 36(12) |
| ISSN: | 1590-3478 |
| Popis: | Although intracranial ependymoma is relatively rare, it is often associated with great clinical aggressiveness and poor overall survival. There are controversies over factors affecting the prognosis of the disease. The aim of this retrospective study was to evaluate factors that may affect the therapeutic outcome and prognosis of intracranial ependymoma by reviewing the medical records of 49 patients who were surgically treated in our hospital between 2001 and 2014. Univariate and multivariate analyses were performed to identify prognostic variables relative to patient and tumor characteristics, and treatment modalities. All 49 patients (24 men and 25 women; mean age 27.6 years) underwent surgical resection, of whom 14 patients also underwent postoperative radiotherapy. Local recurrence was found in 15 (48.8 %) patients, and 22 (51.2 %) patients died during the follow-up periods. The 5-year recurrence rate was 65 % and the survival rate was 51 %. The results of statistical analysis suggested that preoperative extraventricular drainage and surgical resection extent were prognostic factors related to progression-free survival, and that age, surgical resection extent and histological grade were closely associated with survival. Interestingly, there was a significant correlation between the symptom of hydrocephalus and age (P = 0.010), and patients with a better clinical status (KPS ≥ 80) were significantly associated with a lower WHO grade (P = 0.007). In conclusion, we confirmed that surgical resection extent was the major independent factor affecting both recurrence and survival of patients with intracranial ependymoma, while age and WHO grade were prognostic factors affecting survival but not recurrence. |
| Databáze: | OpenAIRE |
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