Effects of Long-Term Cocaine Exposure on Spermatogenesis and Fertility in Peripubertal Male Rats

Autor:	Claudio Teloken, W. Dwayne Lawrence, Chirpriya B. Dhabuwala, Haikun Li, Valal K. George, David J. Grignon
Rok vydání:	1996
Předmět:	Litter (animal) Infertility medicine.medical_specialty Pregnancy business.industry Urology media_common.quotation_subject Fertility medicine.disease Pregnancy rate Follicle-stimulating hormone Endocrinology Internal medicine medicine Luteinizing hormone business Spermatogenesis media_common
Zdroj:	Journal of Urology. 155:327-331
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(01)66654-0
Popis:	Purpose: This study was conducted to investigate the effects of long-term administration of cocaine on spermatogenesis and fertility in adult male rats.Materials and Methods: Thirty-day-old male Sprague-Dawley rats were given cocaine hydro-chloride (15 mg./kg. body weight, corresponding to an average single dose for a heavy cocaine user) either daily or twice weekly (weekend group, cocaine given on Saturday and Sunday) and mated with pregnancy-proven female rats after 100 and 150 days of exposure to the drug. Pregnancy rates and litter birth weights were evaluated. Serum testosterone, follicle stimulating hormone and luteinizing hormone levels were measured in all adult rats. Morphologic analysis of the testis entailed the evaluation of quantitative and qualitative histologic parameters to assess the effect of cocaine on various stages of spermatogenesis.Results: After 100 days of treatment, the rats receiving daily cocaine had a pregnancy rate of only 33 percent versus 86 percent for the controls...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2901a41058340aa2e5caffb801304399 https://doi.org/10.1016/s0022-5347(01)66654-0 Zobrazit plný text záznamu