Dapagliflozin plus saxagliptin add‐on to metformin reduces liver fat and adipose tissue volume in patients with type 2 diabetes

Autor: Nalina Dronamraju, Paul D. Hockings, Lars Johansson, John P.H. Wilding, Jill Maaske, Eva Johnsson, Ricardo Garcia-Sanchez
Jazyk: angličtina
Rok vydání: 2020
Předmět:
nonalcoholic fatty liver disease
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Population
Urology
ectopic fat
Adipose tissue
030209 endocrinology & metabolism
Adamantane
Type 2 diabetes
030204 cardiovascular system & hematology
Saxagliptin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Glucosides
Nonalcoholic fatty liver disease
Internal Medicine
medicine
Humans
Dapagliflozin
saxagliptin
Benzhydryl Compounds
education
glimepiride
sodium‐glucose co‐transporter‐2 inhibitors
education.field_of_study
business.industry
magnetic resonance imaging‐estimated proton density fat fraction
Original Articles
dapagliflozin
Dipeptides
liver fat
medicine.disease
Metformin
Glimepiride
fixed‐dose combination
chemistry
Adipose Tissue
Diabetes Mellitus
Type 2
Liver
Original Article
Drug Therapy
Combination
business
medicine.drug
Zdroj: Diabetes, Obesity & Metabolism
DIABETES OBESITY & METABOLISM
ISSN: 1463-1326
1462-8902
Popis: Aim To assess the effects of dapagliflozin plus saxagliptin plus metformin versus glimepiride plus metformin on liver fat (proton density fat fraction) and visceral and subcutaneous adipose tissue volumes over 52 weeks of treatment. Materials and methods This was a magnetic resonance imaging substudy of a 52‐week, multicentre, randomized, double‐blind, parallel‐group trial that evaluated the efficacy and safety of dapagliflozin 10 mg/day plus saxagliptin 5 mg/day versus titrated glimepiride 1–6 mg (1, 2, 3, 4 or 6 mg) in 82 patients with type 2 diabetes (HbA1c 7.5%–10.5%) on metformin ≥1500 mg/day background. Analyses were exploratory and not controlled for multiplicity; P‐values are nominal. Results Magnetic resonance imaging was performed on 59 patients; liver fat and adipose tissue volumes were analysed for 59 and 57 patients, respectively. There was a significant >30% reduction from baseline in liver fat (P = 0.007) and >10% reduction in adipose tissue volumes (P
Databáze: OpenAIRE
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