Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity
| Autor: | Brižita Đorđević, Bojana Vidović, Jelena Kotur-Stevuljevic, Sanda Dilber, Zorica Knežević-Jugović, Melina T. Kalagasidis-Krušić, Nikola Milašinović |
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| Rok vydání: | 2016 |
| Předmět: |
food.ingredient
Antioxidant General Chemical Engineering Alpha-Lipoic Acid medicine.medical_treatment antioxidant activity 02 engineering and technology lcsh:Chemical technology 010402 general chemistry 01 natural sciences Gelatin Chitosan chemistry.chemical_compound food medicine Organic chemistry lcsh:TP1-1185 Fourier transform infrared spectroscopy microparticles sodium alginate/gelatin alpha-lipoic acid General Chemistry 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences Lipoic acid chemistry Emulsion sodiumal ginate/gelatin lipids (amino acids peptides and proteins) chitosan 0210 nano-technology Nuclear chemistry |
| Zdroj: | Hemijska industrija Hemijska Industrija, Vol 70, Iss 1, Pp 49-58 (2016) |
| Popis: | Alpha-lipoic acidis an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of α-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, α-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of α-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of α-lipoic acid obtained in this study was up to 53.9 %. The structural interaction of α-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of α-lipoic acid was achieved through its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released α-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of α-lipoic acid. [Projekat Ministartsva nauke Republike Srbije, br. III 46010 i br. III46001] |
| Databáze: | OpenAIRE |
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