Adjunctive Subantimicrobial Dose Doxycycline in the Treatment of Chronic Periodontitis in Type 2 Diabetic Patients: A Unique Combination Therapy
| Autor: | Abdelhakim Gomaa, Guindy El, Abdallah Mahmoud, Arafa El-Zamrany |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Combination therapy Strategy and Management Bleeding on probing matrix metalloproteinase-8 subantimicrobial dose doxycycline Gastroenterology 03 medical and health sciences 0302 clinical medicine Scaling and root planing Subantimicrobial dose doxycycline Internal medicine Media Technology medicine General Materials Science Periodontal Probing In patient Marketing Doxycycline business.industry RK1-715 030206 dentistry medicine.disease Chronic periodontitis 030205 complementary & alternative medicine gingival crevicular fluid Dentistry diabetes mellitus periodontal therapy medicine.symptom business medicine.drug |
| Zdroj: | Balkan Journal of Dental Medicine, Vol 22, Iss 1, Pp 32-37 (2018) |
| ISSN: | 2335-0245 |
| Popis: | Background/Aim: To evaluate the effectiveness of combination therapy including subantimicrobial dose doxycycline (SDD) and locally delivered doxycycline (LD) as adjuncts to scaling and root planing (SRP) in the treatment of chronic periodontitis in patients with type 2 diabetes mellitus (T2DM). Material and Methods: Forty patients with controlled T2DM (HbA1c ≤7%) and chronic periodontitis were selected. They were randomly divided into two groups, twenty patients each: Test group (TG, n=20) patients was treated with combination therapy of full mouth SRP, LD gel 10% and SDD 20 mg twice daily for 6 months. Control group (CG, n=20) patients was treated with full mouth SRP only. The periodontal parameters were recorded at baseline, 3, 6 and 9 months and included periodontal probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Gingival crevicular fluid (GCF) samples were collected and a quantitative measurement of matrix metalloproteinase-8 (MMP-8) was carried out by using Enzyme-Linked Immunosorbent Assay (ELIZA) at baseline, 3, 6 and 9 months. Results: Statistically significant reduction in all clinical parameters (PPD, CAL, and BOP) was observed at TG over CG at 3, 6, and 9 months (p |
| Databáze: | OpenAIRE |
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