Histamine in brain — its role in regulation of seizure susceptibility
| Autor: | Hans-Hasso Frey, A. Hashem, R. Scherkl |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Histamine Antagonists Mice Inbred Strains Histamine H1 receptor Pharmacology Ranitidine Mice chemistry.chemical_compound Seizures Internal medicine medicine Animals Electroshock Thioperamide Seizure threshold Dimethindene business.industry Methylhistamines Brain Histidine decarboxylase Anticonvulsant Endocrinology Neurology chemistry Pentylenetetrazole Disease Susceptibility Neurology (clinical) business Histamine medicine.drug |
| Zdroj: | Epilepsy Research. 10:111-118 |
| ISSN: | 0920-1211 |
| Popis: | The influence of drugs affecting the turnover and levels of histamine in brain and histamine antagonists on pentetrazole (PTZ)-induced and electroconvulsive seizure threshold in mice was studied. A 1.5-2-fold rise in histamine brain concentration (induced by treatment with histidine or metoprine), led to a concomitant increase of PTZ-induced seizure threshold. A histidine decarboxylase inhibitor (brocresine) induced a depletion of brain histamine by about 75% for at least 8 h, the seizure threshold was, however, only reduced at 6 and 8 h after the injection. At shorter intervals, the seizure threshold was substantially increased. Treatment with centrally acting H1 antagonists (dimethindene and promethazine) in non-sedative dosage diminished the PTZ seizure threshold significantly; no changes were seen after treatment with H2 and H3 antagonists (oxmetidine, ranitidine, zolantidine or thioperamide) and a H3 agonist (R-alpha-methylhistamine). The electroconvulsive threshold was hardly influenced. It is concluded that histamine has a certain anticonvulsant effect which is mediated through H1 receptors. |
| Databáze: | OpenAIRE |
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