Pharmacokinetics and bioavailability of danofloxacin in swan geese ( Anser cygnoides ) following intravenous, intramuscular, subcutaneous, and oral administrations

Autor:	Duygu Durna Corum, Orhan Corum, Ibrahim Ozan Tekeli, Erdinc Turk, Fatma Ceren Kirgiz, Kamil Uney
Rok vydání:	2022
Předmět:	Pharmacology Cross-Over Studies General Veterinary Area Under Curve Geese Injections Intravenous Animals Administration Oral Biological Availability Injections Intramuscular Anti-Bacterial Agents Half-Life
Zdroj:	Journal of Veterinary Pharmacology and Therapeutics. 45:570-577
ISSN:	1365-2885 0140-7783
DOI:	10.1111/jvp.13086
Popis:	The aim of this study was to determine the pharmacokinetics and bioavailability of danofloxacin in swan geese (Anser cygnoides) after intravenous (IV), intramuscular (IM), subcutaneous (SC), and oral (PO) administrations at 10 mg/kg dose. In this study, eight clinically healthy swan geese were used. The study was performed in four periods according to a crossover design with a 15 days washout period between two administrations. The plasma concentrations of danofloxacin were analyzed using high-performance liquid chromatograph-ultraviolet detection, and pharmacokinetic parameters were estimated by non-compartmental analysis. Following IV administration, terminal elimination half-life (t
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fa891d34bd83bf3584e517b17ce0d6 https://doi.org/10.1111/jvp.13086 Zobrazit plný text záznamu Plný text