Recent developments in persufflation for organ preservation
| Autor: | Catherine G. Min, Klearchos K. Papas |
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| Rok vydání: | 2018 |
| Předmět: |
Alternative methods
Transplantation medicine.medical_specialty Machine perfusion business.industry Organ Preservation Solutions Ischemia Organ Preservation Oxygenation 030230 surgery medicine.disease Warm ischemia Oxygen Perfusion 03 medical and health sciences 0302 clinical medicine Preservation Technique 030220 oncology & carcinogenesis Internal medicine medicine Cardiology Humans Immunology and Allergy business |
| Zdroj: | Current Opinion in Organ Transplantation. 23:330-335 |
| ISSN: | 1087-2418 |
| DOI: | 10.1097/mot.0000000000000526 |
| Popis: | PURPOSE OF REVIEW To summarize current literature and recent findings on the potential of humidified oxygenated gas perfusion (persufflation) as an alternative method for improved organ preservation. RECENT FINDINGS Although there are some conflicting data, the majority of the evidence suggests that persufflation, by enhancing oxygenation, can improve preservation and even rescue organs, including organs with prior exposure to warm ischemia. In some cases, persufflation produced better results than hypothermic machine perfusion. The timing of persufflation is of importance; benefits of persufflation appear to increase as the timing of its administration postprocurement decreases. This may be particularly true for tissues that are more sensitive to ischemia, such as the pancreas prior to islet isolation. Combining oxygen persufflation with nitric oxide and addition of pulsatile flow may provide further benefits and amplify its effects on improving transplant outcomes. SUMMARY Persufflation is a promising, relatively simple, preservation technique that enables improved oxygenation, which provides protection and improvement in the graft condition during preservation and prior to transplantation. More detailed studies are needed to optimize persufflation and evaluate its short and long-term effects in vivo. |
| Databáze: | OpenAIRE |
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