Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate
| Autor: | M. Taourirte, J.-L. Imbach, A. Rochdi, J. L. Barascut, Hassan B. Lazrek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Pyrimidine
Acyclonucleoside Stereochemistry Pharmaceutical Science Alkylation Medicinal chemistry Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Michael addition Drug Discovery Moiety Physical and Theoretical Chemistry Phophonoalkenyl Alkyl chemistry.chemical_classification N-3-alkylation Organic Chemistry Uracil Phosphonate Thymine chemistry Chemistry (miscellaneous) Michael reaction Molecular Medicine |
| Zdroj: | Molecules, Vol 5, Iss 10, Pp 1139-1145 (2000) Molecules Volume 5 Issue 10 Pages 1139-1145 |
| ISSN: | 1420-3049 |
| Popis: | The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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