Dose specification for Ir-192 high dose rate brachytherapy in terms of dose-to-water-in-medium and dose-to-medium-in-medium
| Autor: | Brigitte Reniers, Josef Nilsson, Åsa Carlsson Tedgren, Frank Verhaegen, Hélio Yoriyaz, Maria Persson, Gabriel P. Fonseca |
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| Přispěvatelé: | Promovendi ODB, Radiotherapie, RS: GROW - Oncology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Photon
Radiological and Ultrasound Technology business.industry medicine.medical_treatment Monte Carlo method Brachytherapy brachytherapy Photon energy Stopping power Ir-192 dose-to-water-in-medium High-Dose Rate Brachytherapy Dose specification dose-to-medium-in-medium Nuclear magnetic resonance medicine Radiology Nuclear Medicine and imaging Atomic number Nuclear medicine business |
| Zdroj: | Physics in Medicine and Biology, 60(11), 4565-4579. IOP Publishing Ltd. |
| ISSN: | 0031-9155 |
| Popis: | Dose calculation in high dose rate brachytherapy with (192)Ir is usually based on the TG-43U1 protocol where all media are considered to be water. Several dose calculation algorithms have been developed that are capable of handling heterogeneities with two possibilities to report dose: dose-to-medium-in-medium (Dm,m) and dose-to-water-in-medium (Dw,m). The relation between Dm,m and Dw,m for (192)Ir is the main goal of this study, in particular the dependence of Dw,m on the dose calculation approach using either large cavity theory (LCT) or small cavity theory (SCT). A head and neck case was selected due to the presence of media with a large range of atomic numbers relevant to tissues and mass densities such as air, soft tissues and bone interfaces. This case was simulated using a Monte Carlo (MC) code to score: Dm,m, Dw,m (LCT), mean photon energy and photon fluence. Dw,m (SCT) was derived from MC simulations using the ratio between the unrestricted collisional stopping power of the actual medium and water. Differences between Dm,m and Dw,m (SCT or LCT) can be negligible ( |
| Databáze: | OpenAIRE |
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