Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients
| Autor: | Beatrice Reinisch, Vera Eickel, Claudia Brandt, Angelika Dübbers, Barbara Spellerberg, Barbara C. Kahl, Peter Küster |
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| Rok vydání: | 2008 |
| Předmět: |
Serotype
Adult Male Adolescent Cystic Fibrosis Science Microbial Sensitivity Tests Biology medicine.disease_cause Cystic fibrosis Microbiology Streptococcus agalactiae Infectious Diseases/Bacterial Infections Antibiotic resistance medicine Humans ddc:610 Child Lung Multidisciplinary Infectious Diseases/Respiratory Infections Microbiology/Medical Microbiology medicine.disease medicine.anatomical_structure Staphylococcus aureus Child Preschool Multilocus sequence typing Medicine Female Respiratory tract Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 4, Iss 2, p e4650 (2009) |
| ISSN: | 1932-6203 |
| Popis: | Streptococcus agalactiae is a well-known pathogen for neonates and immunocompromized adults. Beyond the neonatal period, S. agalactiae is rarely found in the respiratory tract. During 2002–2008 we noticed S. agalactiae in respiratory secretions of 30/185 (16%) of cystic fibrosis (CF) patients. The median age of these patients was 3–6 years older than the median age CF patients not harboring S. agalactiae. To analyze, if the S. agalactiae isolates from CF patients were clonal, further characterization of the strains was achieved by capsular serotyping, surface protein determination and multilocus sequence typing (MLST). We found a variety of sequence types (ST) among the isolates, which did not substantially differ from the MLST patterns of colonizing strains from Germany. However serotype III, which is often seen in colonizing strains and invasive infections was rare among CF patients. The emergence of S. agalactiae in the respiratory tract of CF patients may represent the adaptation to a novel host environment, supported by the altered surfactant composition in older CF patients. |
| Databáze: | OpenAIRE |
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