Antimicrobial activity of seven metallic compounds against penicillinase producing and non-penicillinase producing strains of Neisseria gonorrhoeae
| Autor: | A. Z. Meheus, D A Vanden Berghe, M Peeters |
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| Rok vydání: | 1986 |
| Předmět: |
Copper Sulfate
Silver medicine.medical_treatment Dermatology Microbial Sensitivity Tests medicine.disease_cause urologic and male genital diseases Selenious Acid Microbiology chemistry.chemical_compound Minimum inhibitory concentration Selenium medicine Antibacterial agent biology business.industry Thimerosal Proteins Antimicrobial biology.organism_classification Phenylmercury Compounds female genital diseases and pregnancy complications Neisseria gonorrhoeae Silver nitrate Infectious Diseases chemistry Metals Mercuric Chloride Beta-lactamase Silver Nitrate Neisseriaceae Phenylmercuric borate business Copper Research Article |
| Zdroj: | Genitourinary medicine. 62(3) |
| ISSN: | 0266-4348 |
| Popis: | The in vitro activity of seven metallic compounds was tested against penicillinase (beta lactamase) producing strains of Neisseria gonorrhoeae (PPNG) and non-PPNG strains. On a weight basis, the mercurials showed the greatest in vitro activity. Phenylmercuric borate, thiomersal, and mercuric chloride inhibited 90% of all strains at concentrations of 5 mg/l, 5 mg/l, and 20 mg/l respectively. Silver nitrate inhibited 90% of the strains at 80 mg/l and the MIC90 for mild silver protein was 200 mg/l. Copper and selenium salts had lower in vitro activities, inhibiting 90% of all the strains at 320 mg/l and 640 mg/l respectively. Silver nitrate and the six other compounds tested showed equal activities against PPNG and non-PPNG strains. This finding supports the recommendation for prophylaxis of gonococcal conjunctivitis of the newborn with 1% silver nitrate eye drops. |
| Databáze: | OpenAIRE |
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