Obesity and Risk for Second Malignant Neoplasms in Childhood Cancer Survivors: A Case–Control Study Utilizing the California Cancer Registry
| Autor: | Leena Chehab, Dennis Deapen, Diana J. Moke, David R. Freyer, Ann S. Hamilton |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Epidemiology Overweight California Article Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Cancer Survivors Risk Factors Neoplasms Internal medicine medicine Humans Obesity Registries Young adult Risk factor Child business.industry Case-control study Infant Cancer Neoplasms Second Primary medicine.disease Cancer registry 030104 developmental biology Oncology Case-Control Studies Child Preschool 030220 oncology & carcinogenesis Female medicine.symptom business Body mass index |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 28:1612-1620 |
| ISSN: | 1538-7755 1055-9965 |
| Popis: | Background: Obesity is a known modifiable risk factor associated with adverse outcomes in children with cancer. We sought to determine whether obesity during childhood cancer treatment increases risk for second malignant neoplasms (SMN). Methods: In this case–control study, cases (with SMN) and controls (with a single-primary cancer) were selected from the California Cancer Registry who had primary cancer diagnosed Results: A total of 59 cases and 130 controls were included. Median age at primary cancer diagnosis was 6 years, 64.5% were male, median time from primary cancer to SMN was 7.5 years, and 31.7% were obese or overweight. In matched multivariable analyses, there were elevated but nonsignificant associations between SMN and higher BMI Z-score at diagnosis [OR 1.27 (0.99–1.63)] and higher BMI categories at diagnosis [adjusted OR (aOR) overweight, 1.25 (0.55–2.52); aOR obese, 2.51 (1.00–6.29)]. There was a significantly increased risk for SMN among patients who were obese at both diagnosis and EOT [aOR, 4.44 (1.37–14.34)]. Conclusions: This study suggests that obesity during childhood cancer treatment may be associated with increased risk for SMNs, particularly among those obese throughout therapy. Impact: Additional studies to confirm these findings and to develop interventions have the potential to impact SMN development in children with cancer. |
| Databáze: | OpenAIRE |
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