Modulation of brain activation during executive functioning in autism with citalopram
| Autor: | Christine Ecker, Eileen Daly, Clodagh M. Murphy, Dene Robertson, Robert Wichers, Declan G. Murphy, Vladimira Stoencheva, James Findon, Katya Rubia, Vincent Giampietro, Auke Jelsma, Grainne M. McAlonan |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Visual Analog Scale Brain activity and meditation Autism Spectrum Disorder Citalopram Molecular neuroscience Predictive markers behavioral disciplines and activities Article lcsh:RC321-571 Cuneus 03 medical and health sciences Cellular and Molecular Neuroscience Executive Function Young Adult 0302 clinical medicine Double-Blind Method mental disorders medicine Humans Attention ddc:610 lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Temporal cortex Brain Mapping Cross-Over Studies medicine.diagnostic_test Brain Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Autism spectrum disorder Autism Female Serotonin Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Translational Psychiatry Wichers, R H, Findon, J L, Jelsma, A, Giampietro, V, Stoencheva, V, Robertson, D M, Murphy, C M, McAlonan, G, Ecker, C, Rubia, K, Murphy, D G M & Daly, E M 2019, ' Modulation of brain activation during executive functioning in autism with citalopram ', Translational psychiatry, vol. 9, no. 1, 286 . https://doi.org/10.1038/s41398-019-0641-0 Translational Psychiatry, Vol 9, Iss 1, Pp 1-11 (2019) |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-019-0641-0 |
| Popis: | Adults with autism spectrum disorder (ASD) are frequently prescribed selective serotonin reuptake inhibitors (SSRIs). However, there is limited evidence to support this practice. Therefore, it is crucial to understand the impact of SSRIs on brain function abnormalities in ASD. It has been suggested that some core symptoms in ASD are underpinned by deficits in executive functioning (EF). Hence, we investigated the role of the SSRI citalopram on EF networks in 19 right-handed adult males with ASD and 19 controls who did not differ in gender, age, IQ or handedness. We performed pharmacological functional magnetic resonance imaging to compare brain activity during two EF tasks (of response inhibition and sustained attention) after an acute dose of 20 mg citalopram or placebo using a randomised, double-blind, crossover design. Under placebo condition, individuals with ASD had abnormal brain activation in response inhibition regions, including inferior frontal, precentral and postcentral cortices and cerebellum. During sustained attention, individuals with ASD had abnormal brain activation in middle temporal cortex and (pre)cuneus. After citalopram administration, abnormal brain activation in inferior frontal cortex was ‘normalised’ and most of the other brain functional differences were ‘abolished’. Also, within ASD, the degree of responsivity in inferior frontal and postcentral cortices to SSRI challenge was related to plasma serotonin levels. These findings suggest that citalopram can ‘normalise’ atypical brain activation during EF in ASD. Future trials should investigate whether this shift in the biology of ASD is maintained after prolonged citalopram treatment, and if peripheral measures of serotonin predict treatment response. |
| Databáze: | OpenAIRE |
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