Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality: Age Gene/Environment Susceptibility-Reykjavik Study
| Autor: | Gunnar Gudmundsson, David C. Christiani, Hiroshi Honda, Mizuki Nishino, David A. Lynch, Akinori Hata, Tetsuro Araki, Takuya Hino, Osamu Honda, Vilmundur Gudnason, Noriyuki Tomiyama, Rachel K. Putman, Gary M. Hunninghake, Hiroto Hatabu, Raul San Jose Estepar, Kousei Ishigami, Masahiro Jinzaki, George R. Washko, Masahiro Yanagawa, Takeshi Kamitani, Takeshi Johkoh, Elias F. Gudmundsson, Yoshitake Yamada, Tomoyuki Hida, Vladimir I. Valtchinov, Junwei Lu |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
BMI body mass index R895-920 Gastroenterology Article Pulmonary fibrosis 030218 nuclear medicine & medical imaging OS overall survival TB traction bronchiectasis TBI-R2 traction bronchiectasis/bronchiolecetasis index on Round 2 Medical physics. Medical radiology. Nuclear medicine 03 medical and health sciences 0302 clinical medicine Usual interstitial pneumonia Internal medicine medicine AGES-Reykjavik Study Age Gene/Environment Susceptibility-Reykjavik Study Radiology Nuclear Medicine and imaging Honeycombing Interstitial lung abnormality Traction bronchiectasis Age Gene/Environment Susceptibility-Reykjavik Study Lung Bronchiectasis Proportional hazards model business.industry Hazard ratio Interstitial lung disease medicine.disease HR hazard ratio medicine.anatomical_structure 030220 oncology & carcinogenesis TBI traction bronchiectasis/bronchiolecetasis index ILD interstitial lung disease ILA interstitial lung abnormalities business |
| Zdroj: | European Journal of Radiology Open, Vol 8, Iss, Pp 100334-(2021) European Journal of Radiology Open |
| ISSN: | 2352-0477 |
| Popis: | Highlights • TB progressed in 58.4 % (191/327). More than 90 % of participants with TBI = 2 or 3 (51/56) had TB progression. • TB progression was associated with increased mortality (adjusted HR = 1.68, P Purpose The aim of this study is to assess the role of traction bronchiectasis/bronchiolectasis and its progression as a predictor for early fibrosis in interstitial lung abnormalities (ILA). Methods Three hundred twenty-seven ILA participants out of 5764 in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study who had undergone chest CT twice with an interval of approximately five-years were enrolled in this study. Traction bronchiectasis/bronchiolectasis index (TBI) was classified on a four-point scale: 0, ILA without traction bronchiectasis/bronchiolectasis; 1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; 2, ILA with mild to moderate traction bronchiectasis; 3, ILA and severe traction bronchiectasis and/or honeycombing. Traction bronchiectasis (TB) progression was classified on a five-point scale: 1, Improved; 2, Probably improved; 3, No change; 4, Probably progressed; 5, Progressed. Overall survival (OS) among participants with different TB Progression Score and between the TB progression group and No TB progression group was also investigated. Hazard radio (HR) was estimated with Cox proportional hazards model. Results The higher the TBI at baseline, the higher TB Progression Score (P |
| Databáze: | OpenAIRE |
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