| Autor: |
Julia Ware, Malgorzata E. Wilinska, Yue Ruan, Janet M. Allen, Charlotte K. Boughton, Sara Hartnell, Lia Bally, Carine de Beaufort, Rachel E. J. Besser, Fiona M. Campbell, Katharine Draxlbauer, Daniela Elleri, Mark L. Evans, Elke Fröhlich-Reiterer, Atrayee Ghatak, Sabine E. Hofer, Thomas M. Kapellen, Lalantha Leelarathna, Julia K. Mader, Womba M. Mubita, Parth Narendran, Tina Poettler, Birgit Rami-Merhar, Martin Tauschmann, Tabitha Randell, Hood Thabit, Ajay Thankamony, Nicola Trevelyan, Roman Hovorka |
| Přispěvatelé: |
Ware, Julia [0000-0002-4497-0979], Boughton, Charlotte K [0000-0003-3272-9544], Besser, Rachel EJ [0000-0002-4645-6324], Evans, Mark L [0000-0001-8122-8987], Leelarathna, Lalantha [0000-0001-9602-1962], Mader, Julia K [0000-0001-7854-4233], Thabit, Hood [0000-0001-6076-6997], Hovorka, Roman [0000-0003-2901-461X], Apollo - University of Cambridge Repository |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Ware, Julia; Wilinska, Malgorzata E; Ruan, Yue; Allen, Janet M; Boughton, Charlotte K; Hartnell, Sara; Bally, Lia; de Beaufort, Carine; Besser, Rachel E J; Campbell, Fiona M; Draxlbauer, Katharine; Elleri, Daniela; Evans, Mark L; Fröhlich-Reiterer, Elke; Ghatak, Atrayee; Hofer, Sabine E; Kapellen, Thomas M; Leelarathna, Lalantha; Mader, Julia K; Mubita, Womba M; ... (2022). Safety of User-Initiated Intensification of Insulin Delivery Using Cambridge Hybrid Closed-Loop Algorithm. (In Press). Journal of diabetes science and technology, p. 19322968221141924. Diabetes Technology Society 10.1177/19322968221141924 |
| ISSN: |
1932-2968 |
| DOI: |
10.1177/19322968221141924 |
| Popis: |
Objective: Many hybrid closed-loop (HCL) systems struggle to manage unusually high glucose levels as experienced with intercurrent illness or pre-menstrually. Manual correction boluses may be needed, increasing hypoglycemia risk with overcorrection. The Cambridge HCL system includes a user-initiated algorithm intensification mode (“Boost”), activation of which increases automated insulin delivery by approximately 35%, while remaining glucose-responsive. In this analysis, we assessed the safety of “Boost” mode. Methods: We retrospectively analyzed data from closed-loop studies involving young children (1-7 years, n = 24), children and adolescents (10-17 years, n = 19), adults (≥24 years, n = 13), and older adults (≥60 years, n = 20) with type 1 diabetes. Outcomes were calculated per participant for days with ≥30 minutes of “Boost” use versus days with no “Boost” use. Participants with Results: Eight weeks of data for 76 participants were analyzed. There was no difference in time spent 300 mg/dL was 1.39 percentage points (1.01 to 1.77; P < .001) higher on “Boost” days, with higher mean glucose and lower time in target range ( P < .001). Conclusions: Use of an algorithm intensification mode in HCL therapy is safe across all age groups with type 1 diabetes. The higher time in hyperglycemia observed on “Boost” days suggests that users are more likely to use algorithm intensification on days with extreme hyperglycemic excursions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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