Genetic and environmental factors and serum hormones, and risk of estrogen receptor-positive breast cancer in pre- and postmenopausal Japanese women
| Autor: | Kanako Hagio, Hiroko Yamashita, Jiazhi Guo, Motoi Baba, Akiko Tamakoshi, Naoko Ishida, Hirotaka Iwase, Nobuyasu Yoshimoto, Koshi Nakamura, Tatsuya Toyama, Aiko Sueta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Breast cancer incidence in Japanese women has more
0301 basic medicine Oncology medicine.medical_specialty Breast surgery medicine.medical_treatment Breastfeeding Estrogen receptor 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Internal medicine medicine Gynecology business.industry Incidence (epidemiology) genetic variants estrogen receptor-positive medicine.disease 25-hydroxyvitamin D 030104 developmental biology 030220 oncology & carcinogenesis risk predictor Breast disease Risk assessment business Body mass index |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 1328-1615 |
| Popis: | // Jiazhi Guo 1 , Aiko Sueta 2 , Koshi Nakamura 3 , Nobuyasu Yoshimoto 4 , Motoi Baba 1 , Naoko Ishida 1 , Kanako Hagio 1 , Tatsuya Toyama 4 , Hirotaka Iwase 2 , Akiko Tamakoshi 3 and Hiroko Yamashita 1 1 Department of Breast Surgery, Hokkaido University Hospital, Sapporo, Japan 2 Department of Breast and Endocrine Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan 3 Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan 4 Department of Breast Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Correspondence to: Hiroko Yamashita, email: hirokoy@huhp.hokudai.ac.jp Keywords: breast cancer, estrogen receptor-positive, risk predictor, genetic variants, 25-hydroxyvitamin D Abbreviations: ER: estrogen receptor, HER2: human epidermal growth factor receptor type 2, SNP: single nucleotide polymorphism, ROC: receiver-operating characteristic, AUC: area under the curve Received: July 03, 2017 Accepted: August 04, 2017 Published: August 11, 2017 ABSTRACT Breast cancer incidence in Japanese women has more than tripled over the past two decades. We have previously shown that this marked increase is mostly due to an increase in the estrogen receptor (ER)-positive, HER2-negative subtype. We conducted a case–control study; ER-positive, HER2-negative breast cancer patients who were diagnosed since 2011 and women without disease were recruited. Environmental factors, serum levels of testosterone and 25-hydroxyvitamin D, and common genetic variants reported as predictors of ER-positive breast cancer or found in Asian women were evaluated between patients and controls in pre- and postmenopausal women. To identify important risk predictors, risk prediction models were created by logistic regression models. In premenopausal women, two environmental factors (history of breastfeeding, and history of benign breast disease) and four genetic variants (TOX3-rs3803662, ESR1-rs2046210, 8q24-rs13281615, and SLC4A7-rs4973768) were considered to be risk predictors, whereas three environmental factors (body mass index, history of breastfeeding, and hyperlipidemia), serum levels of testosterone and 25-hydroxyvitamin D, and two genetic variants (TOX3-rs3803662 and ESR1-rs2046210) were identified as risk predictors. Inclusion of common genetic variants and serum hormone measurements as well as environmental factors improved risk assessment models. The decline in the birthrate according to recent changes of lifestyle might be the main cause of the recent notable increase in the incidence of ER-positive breast cancer in Japanese women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|