Acute effects of short term use of ecigarettes on Airways Physiology and Respiratory Symptoms in Smokers with and without Airway Obstructive Diseases and in Healthy non smokers
| Autor: | Christina Gratziou, Anastasios Palamidas, Sofia-Antiopi Gennimata, Stamatoula Tsikrika, Paraskevi Katsaounou, Sofia Vakali, George Kaltsakas, Nikolaos Koulouris |
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| Rok vydání: | 2016 |
| Předmět: |
Health (social science)
Epidemiology Physiology e-cigarette airway inflammation Health Professions (miscellaneous) law.invention Nicotine 03 medical and health sciences 0302 clinical medicine Airway resistance law respiratory function medicine respiratory impedance Respiratory function 030212 general & internal medicine Respiratory system Asthma Breath test COPD medicine.diagnostic_test business.industry lcsh:Public aspects of medicine Public Health Environmental and Occupational Health airways resistance lcsh:RA1-1270 medicine.disease respiratory tract diseases electronic cigarette 030228 respiratory system behavior and behavior mechanisms business Electronic cigarette medicine.drug Research Paper |
| Zdroj: | Tobacco Prevention & Cessation Tobacco Prevention and Cessation, Vol 3, Iss March (2017) |
| ISSN: | 2459-3087 |
| Popis: | Background Although the use of e-cigarettes is increasing worldwide, their short and long-term effects remain undefined. We aimed to study the acute effect of short-term use of e-cigarettes containing nicotine on lung function and respiratory symptoms in smokers with airways obstructive disease (COPD, asthma), "healthy" smokers, and healthy never smokers. Methods Respiratory symptoms, vital signs, exhaled NO, airway temperature, airway resistance (Raw), specific airway conductance (sGaw) and single nitrogen breath test were assessed before and immediately after short term use of an e-cigarette containing 11mg of nicotine among adults with COPD, asthma, "healthy" smokers, and never-smokers. The effect of the use of nicotine-free e-cigarettes among "healthy" never smokers was also studied. Results The majority of participants reported acute cough. Short term use of nicotine e-cigarettes was associated: a) with increased heart rate in all subjects except in the COPD group, b) decreased oxygen saturation in "healthy" and COPD smokers, c) increased Raw in asthmatic smokers, "healthy" smokers, and healthy never smokers, d) decreased sGaw in healthy subjects, and e) changed slope of phase III curve in asthmatic smokers. Short-term use of nicotine-free e-cigarettes increased Raw and decreased sGaw among healthy never smokers. Conclusions Short-term use of an e-cigarette has acute effects on airways physiology and respiratory symptoms in COPD smokers, asthmatic smokers, "healthy" smokers and healthy never smokers. E-cigarette use was associated with effects in "healthy" never smokers irrespectively of nicotine concentration. More studies are needed to investigate both short and long-term effects of e-cigarette use. |
| Databáze: | OpenAIRE |
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