CT perfusion in peripheral arterial disease-hemodynamic differences before and after revascularisation
Autor: | Martin Banyai, Klaus Strobel, Sebastian Mafeld, Martin W. Huellner, Bert-Ram Sah, Patrick Veit-Haibach, Johannes T. Heverhagen |
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Přispěvatelé: | University of Zurich, Sah, Bert-Ram |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Hemodynamics Perfusion scanning Blood volume 610 Medicine & health Volumetric CT 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences Peripheral Arterial Disease 0302 clinical medicine Computed Tomography Internal medicine Occlusion medicine 2741 Radiology Nuclear Medicine and Imaging Humans Radiology Nuclear Medicine and imaging Ankle Brachial Index medicine.diagnostic_test business.industry Contrast media Interventional radiology General Medicine Blood flow 10181 Clinic for Nuclear Medicine medicine.disease Perfusion imaging Perfusion Stenosis Cardiology Radiology business Tomography X-Ray Computed |
Zdroj: | European Radiology Veit-Haibach, Patrick; Huellner, Martin W; Banyai, Martin; Mafeld, Sebastian; Heverhagen, Johannes; Strobel, Klaus; Sah, Bert-Ram (2021). CT perfusion in peripheral arterial disease-hemodynamic differences before and after revascularisation. European radiology, 31(8), pp. 5507-5513. Springer-Verlag 10.1007/s00330-021-07692-5 |
DOI: | 10.5167/uzh-202039 |
Popis: | Objectives The purpose of this study was the assessment of volumetric CT perfusion (CTP) of the lower leg musculature in patients with symptomatic peripheral arterial disease (PAD) before and after interventional revascularisation. Methods Twenty-nine consecutive patients with symptomatic PAD of the lower extremities requiring interventional revascularisation were assessed prospectively. All patients underwent a CTP scan of the lower leg, and hemodynamic and angiographic assessment, before and after intervention. Ankle-brachial pressure index (ABI) was determined. CTP parameters were calculated with a perfusion software, acting on a no outflow assumption. A sequential two-compartment model was used. Differences in CTP parameters were assessed with non-parametric tests. Results The cohort consisted of 24 subjects with an occlusion, and five with a high-grade stenosis. The mean blood flow before/after (BFpre and BFpost, respectively) was 7.42 ± 2.66 and 10.95 ± 6.64 ml/100 ml*min−1. The mean blood volume before/after (BVpre and BVpost, respectively) was 0.71 ± 0.35 and 1.25 ± 1.07 ml/100 ml. BFpost and BVpost were significantly higher than BFpre and BVpre in the treated limb (p = 0.003 and 0.02, respectively), but not in the untreated limb (p = 0.641 and 0.719, respectively). Conclusions CTP seems feasible for assessing hemodynamic differences in calf muscles before and after revascularisation in patients with symptomatic PAD. We could show that CTP parameters BF and BV are significantly increased after revascularisation of the symptomatic limb. In the future, this quantitative method might serve as a non-invasive method for surveillance and therapy control of patients with peripheral arterial disease. Key Points • CTP imaging of the lower limb in patients with symptomatic PAD seems feasible for assessing hemodynamic differences before and after revascularisation in PAD patients. • This quantitative method might serve as a non-invasive method, for surveillance and therapy control of patients with PAD. |
Databáze: | OpenAIRE |
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