Early life factors and their relevance for markers of cardiometabolic risk in early adulthood

Autor: Yifan Hua, Juliana Nyasordzi, Thomas Remer, Janina Goletzke, Johanna Conrad, Anette E. Buyken, Christian Herder, Stefan A. Wudy, Michael Roden, Helena Ludwig-Walz
Rok vydání: 2021
Předmět:
Male
medicine.medical_specialty
Time Factors
Adolescent
Offspring
Endocrinology
Diabetes and Metabolism
Birth weight
Breastfeeding
Medicine (miscellaneous)
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Risk Assessment
Body Mass Index
Young Adult
03 medical and health sciences
Sex Factors
0302 clinical medicine
Pregnancy
Germany
Humans
Medicine
Longitudinal Studies
Prospective Studies
Young adult
Inflammation
Metabolic Syndrome
Nutrition and Dietetics
business.industry
Obstetrics
Fatty liver
Confounding
Age Factors
Cardiometabolic Risk Factors
medicine.disease
Gestational Weight Gain
Fatty Liver
Breast Feeding
Prenatal Exposure Delayed Effects
Body Composition
Gestation
Female
Insulin Resistance
Waist Circumference
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Weight gain
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 31:2109-2121
ISSN: 0939-4753
Popis: Early life exposures could be pertinent risk factors of cardiometabolic diseases in adulthood. We assessed the prospective associations of early life factors with markers of cardiometabolic risk among healthy German adults.We examined 348 term-born DONALD Study participants with measurement of fasting blood at the age of 18-24 years to assess metabolic indices: fatty liver index (FLI), hepatic steatosis index (HSI), pro-inflammatory score and insulin sensitivity (HOMA2-%S). Early life factors (maternal weight in early pregnancy, maternal early pregnancy BMI, gestational weight gain (GWG), maternal age, birth weight and full breastfeeding (17 weeks)) were assessed at enrolment of the offspring into the study. Multivariable linear regression models were used to analyze associations between early life factors and markers of cardiometabolic risk in early adulthood with adjustment for potential confounders. A higher early pregnancy BMI was related to notably higher levels of offspring FLI, HSI, pro-inflammatory score and a lower HOMA2-%S (all p 0.0001). Similarly, a higher gestational weight gain was associated with a higher FLI (p = 0.044), HSI (p = 0.016), pro-inflammatory score (p = 0.032) and a lower HOMA2-%S among females (p = 0.034). Full breastfeeding was associated with a lower adult FLI (p = 0.037). A casual mediation analysis showed that these associations were mediated by offspring adult waist circumference (WC).This study suggests that early pregnancy BMI, gestational weight gain, and full breastfeeding are relevant for offspring markers of cardiometabolic risk which seems to be mediated by body composition in young adulthood.
Databáze: OpenAIRE
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