Correlation between blood rheological properties and red blood cell indices(MCH, MCV, MCHC) in healthy women
| Autor: | Panagiotis Tsikouras, Eva Velten, Attila Demirhan, Georg-Friedrich von Tempelhoff, Werner Rath, Olga Schelkunov, Roland Csorba |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Erythrocyte Indices
0301 basic medicine medicine.medical_specialty Physiology Blood viscosity 030204 cardiovascular system & hematology Klinikai orvostudományok Correlation 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Humans Medicine Prospective Studies Plasma viscosity Red blood cell indices Pregnancy medicine.diagnostic_test business.industry Hematology Blood flow Orvostudományok Middle Aged Blood Viscosity medicine.disease Healthy Volunteers Pathophysiology Gynaecological surgery Cross-Sectional Studies 030104 developmental biology Endocrinology Immunology Female Rheology Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology |
| Popis: | OBJECTIVE Structure and mechanical properties of red blood cells are markedly influenced by pathophysiology of many diseases which in turn potentially impair microcirculatory blood flow. The physiological association between blood rheological parameters and red blood cell indices was investigated in otherwise healthy unselected mid-age women prior to elective gynaecological surgery. METHODS Red Blood Cell-deformability (RBC 1.2, 3.0; 6.0, 12.0; 30.0, 60.0) during exposure to low (RBC 1.2, 3.0), moderate (RBC 16.0, 12.0) and high shear forces (RBC 30.0, 60.0; Rheodyn; Myrenne), -aggregation (MA1; Myrenne) during low shear (E1; 4-1 S) and in stasis (E0) and plasma viscosity (Pv; KSV 1; Fresenius) were correlated with red blood cell indices (RBC-I: MCV, MCH and MCHC) and subjects' characteristics in 286 healthy women the day before undergoing gynaecologic standard surgery. Women with known pregnancy, malign-, infective-, chronic-disease or extreme BMI ( 40 Kg/m2) were excluded from this trial. RESULTS From June 2014 to December 2014 a total of 286 healthy women (age: 46.5±17.6 y; BMI: 25.5±5.2 kg/m2) were eligible for inclusion into this prospective evaluation. Pv (mean±SD: 1.17±0.12 mPa s) and RBC aggregation (E0:12.6±6.3; E1:17.9±7.3) were not significantly correlated with RBC-I but with age and BMI. In contrast, RBC-deformability correlated significantly with MCV and MCH but significantly inversely correlated with MCHC. Deformability significantly increased with age but was unaffected by BMI of women. The correlation between RBC-I and RBC deformability was most remarkable during moderate shear force exposure. Neither haemoglobin nor haematocrit were correlated with RBC deformability or RBC-I. CONCLUSIONS Cell volume and haemoglobin content had a strong impact on deformability in apparently healthy mid age women, whereas low MCHC and large MCV were associated with an increase in deformability while high MCHC and small MCV correlated with increased rigidity of RBC. BMI had no impact on deformability while age was associated with an increase in all determinants of blood viscosity. RBC aggregability was not affected by MCV, MCHC or MCH in mid-age women. |
| Databáze: | OpenAIRE |
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