Decline in Meningococcal Antibody Levels in African Children 5 Years after Vaccination and the Lack of an Effect of Booster Immunization
| Autor: | Linda L. Gheesling, Arun Menon, Stephen Allen, Wallis E. DeWitt, Susan H. Turner, Jim Todd, Serign J. Ceesay, Brian D. Plikaytis, George M. Carlone, Brian Greenwood, Kabir Cham |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Immunization Secondary Enzyme-Linked Immunosorbent Assay Meningococcal Vaccines Meningococcal vaccine Booster dose Meningitis Meningococcal Neisseria meningitidis Meningococcal disease Polysaccharide Vaccine Humans Immunology and Allergy Medicine Child business.industry Hemagglutination Vaccination Antibody titer Infant medicine.disease Antibodies Bacterial Malaria Infectious Diseases Immunization Child Preschool Bacterial Vaccines Immunology Female Gambia business Meningitis |
| Zdroj: | Journal of Infectious Diseases. 167:1212-1216 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Antibodies to group A meningococcal polysaccharide were measured by hemagglutination (HA) and by ELISA in sera obtained from Gambian children before vaccination and 3 weeks, 2 years, and 5 years after vaccination with a group A + group C meningococcal capsular polysaccharide vaccine. Children were 1-4 years old at the time of vaccination. Most showed a good initial response to vaccination, including those aged 1-2 years. However, antibody titers declined progressively during follow-up, and 5 years after vaccination, antibody titers measured by both HA and ELISA had returned to prevaccination levels. This decline was not influenced significantly by a booster dose of vaccine given 2 years after initial immunization. Administration of malaria chemoprophylaxis reduced the rate at which antibody levels fell after initial immunization. Sustained protection of children against group A meningococcal disease will require the development of vaccines that are immunogenic in infants and that can induce T cell memory. |
| Databáze: | OpenAIRE |
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