Biological Role of α-Lactalbumin: A Review
| Autor: | K.E. Ebner, Urs Brodbeck |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Lactalbumin
chemistry.chemical_classification animal structures Biology Molecular biology Homology (biology) chemistry.chemical_compound Enzyme chemistry Biosynthesis Biochemistry Albumins Genetics Animals Cattle Female Animal Science and Zoology Lactose Binding site Lysozyme Peptide sequence Food Science |
| Zdroj: | Journal of Dairy Science. 51:317-322 |
| ISSN: | 0022-0302 |
| DOI: | 10.3168/jds.s0022-0302(68)86984-x |
| Popis: | The biological role of α -lactalbumin has been elucidated recently. It is one of two proteins required for the lactose synthetase enzyme, the enzyme responsible for the biosynthesis of lactose. This enzyme requires an A protein, a B protein ( α -lactalbumin), substrates and metal for activity. α -Lactalbumin, by itself, does not have any catalytic activity and, hence, the elucidation of its function came about in an indirect manner. α -Lactalbumins isolated from various sources have about the same activity when assayed with bovine A protein in the lactose synthetase assay. However, α -lactalbumin from nonruminant sources will not react with antisera to bovine α -lactalbumin. Such studies indicate that the immunological binding sites and enzymic catalytic sites are distinct. Recent work also has indicated a high degree of homology in the amino acid sequence between bovine α -lactalbumin and hen's egg-white lysozyme, suggesting that both proteins arose from a common ancestral gene. |
| Databáze: | OpenAIRE |
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